Open Access Research article

A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine

Michael T White1*, Philip Bejon23, Ally Olotu2, Jamie T Griffin1, Kalifa Bojang4, John Lusingu5, Nahya Salim6, Salim Abdulla6, Nekoye Otsyula7, Selidji T Agnandji89, Bertrand Lell89, Kwaku Poku Asante10, Seth Owusu-Agyei10, Emmanuel Mahama10, Tsiri Agbenyega11, Daniel Ansong11, Jahit Sacarlal1213, John J Aponte1214 and Azra C Ghani1

Author Affiliations

1 MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK

2 KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute, Kilifi, Kenya

3 Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, UK

4 Medical Research Council Unit, Fajara, The Gambia

5 National Institute for Medical Research, Tanga Centre, Tanga, Tanzania

6 Ifakara Health Institute, Bagamoyo, Tanzania

7 Kenya Medical Research Institute, and US Army Medical Research Unit–Kenya, Nairobi, Kenya

8 Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon

9 Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany

10 Kintampo Health Research Centre, Kintampo, Ghana

11 School of Medical Sciences, Kumasi, Ghana

12 Centro de Investigação em Saúde de Manhiça, Manhiça, Mozambique

13 Faculdade de Medicina, Universidade Eduardo Mondlane, Avenida do Zimbabwe, Maputo, Mozambique

14 Barcelona Centre for International Health Research (CRESIB), Universitat de Barcelona, Barcelona, Spain

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BMC Medicine 2014, 12:117  doi:10.1186/s12916-014-0117-2

Published: 10 July 2014

Additional files

Additional file 1:

Information on the ethical approval regarding the trials including in this analysis.

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Open Data

Additional file 2:

Supplementary statistical methods and additional analyses.

Format: DOCX Size: 1.5MB Download file

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