Table 1

Selected non-major histocompatibility complex susceptibility genes for systemic sclerosis which were confirmed in at least two independent studies.

Approximate OR

Potential Function


BANK1

1.2-1.5*

Lymphocyte activation - B cells

BLK

1.2-1.5

Lymphocyte activation - B cells

CD247

1.2-1.5*

Lymphocyte activation - T cells

CD226

1.0-1.2

Lymphocyte activation - T cells

IRF5

1.2-1.5

Innate immune signaling - Interferon pathway

MIF

1.0-1.2

Adhesion molecule on endothelial cells

PTPN22

1.2-1.5

Lymphocyte activation - T cells

STAT4

1.2-1.5

Innate immune signaling and lymphocyte activation - T cells

TNFSF4

1.2-1.5

Lymphocyte activation - T cells and B cells


*The minor allele is protective. The inverse ratio OR is reported.

Assassi et al. BMC Medicine 2013 11:9   doi:10.1186/1741-7015-11-9

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