BCNU is relatively unstable in tissues. A) Incubation of BCNU in mouse brain homogenates showed intact BCNU only up to 15 minutes, but at 30 minutes, there was no trace of BCNU. B) Intact BCNU, however, could be detected in the blood for up to 30 minutes. BCNU, 1, 3 bis (2-chloroethyl)-1-nitrosourea.
Hayes et al. BMC Medicine 2013 11:81 doi:10.1186/1741-7015-11-81