Table 1

Significant associations of autoimmune diseases in first degree relatives.

Proband´s disease

Author

Disease in first degree relatives

References


Autoimmune thyroid disease

Boelaert et al.

AdD, CD, IBD, MG, MS, PA, RA, SLE, T1D, VIT

[33]

Hemminki et al.

In parent: AdD, IIM, MG, PA, RA, T1D, UC

[34]

In sibling: Discoid lupus erythematosus, localized SSc, T1D

In parent and sibling: SLE

Type 1 diabetes

Bottazo et al.

AITD

[36]

Anaya et al.

AITD

[37]

Wagner et al.

AITD,CD, PSO, RA, VIT

[38]

Hemminki et al.

In parent: AdD, AITD, AS, CD, PA, PBC, RA, SLE, UC, WG

[39]

In sibling: AdD, AITD, CD

In parent and sibling: RA

Lebenthal et al.

AITD, CD

[41]

Systemic lupus erythematosus

Criswell et al.

AITD

[35]

Alarcon-Segovia et al.

AITD, IIM, RA, SSc

[42]

Priori et al.

AITD, RA, T1D, VIT

[43]

Corporaal et al.

MS, RA

[44]

Rheumatoid arthritis

Lin et al.

AITD, T1D,

[45]

Thomas et al.

T1D

[46]

Hemminki et al.

In parent: AITD, AS, Localized SSc, PA, PSO, SLE, SS, SSc, WG

[47]

In sibling: PSO, SLE

Jawaheer et al.

AITD

[48]

Multiple sclerosis

Barcellos et al.

AITD, PSO, RA, T1D

[32]

Criswell et al.

PSO

[35]

Broadley et al.

AITD

[49]

Deretzi et al.

AITD, IBD, PSO, T1D

[50]

Heinzlef et al.

AITD, RA, T1D, VIT

[51]

Henderson et al.

AS

[52]

Marrosu et al.

T1D

[53]

Nielsen et al.

AdD, CrD, PAN,

[55]

Systemic sclerosis

Arora-Singh et al.

AITD, RA, SLE,

[57]

Hudson et al.

AITD, PBC, RA, SLE, SS

[58]

Koumakis et al.

AITD, RA, SLE, SS

[59]

Sjögren's syndrome

Reveille et al.

AITD, MS, SLE, SSc

[61]

Anaya et al.

AITD, RA, SLE

[62]

Inflammatory bowel disease

Criswell et al.

MS

[35]

Ulcerative colitis

Hemminki et al.

In parent: AITD, AS, CrD, MS, PA, PAN, PSO, RA, SLE, T1D

[63]

In sibling: AS, CrD

In parent and sibling: CrD, PSO

Crohn's disease

Hemminki et al.

In parent: AS, PSO, UC

[63]

In sibling: AS, UC

In parent and sibling: RA, UC

In twins: UC

Vitiligo

Alkhateeb et al.

AdD, AITD, MG, PA, SLE, SSc

[64]

Laberge et al.

AdD, AITD, PA, PSO, RA

[65]

Zhang et al.

AA, PSO, RA

[66]

Juvenile rheumatoid arthritis

Prahalad et al.

AITD

[67]

Huang et al.

AITD, AS, PSO, SLE

[68]

Juvenile lupus erythematosus

Huang et al.

AITD, AS, MG

[68]

Inflammatory idiopathic myositis

Ginn et al.

AITD, PA, PSO, RA, SS, T1D

[70]

Celiac disease

Petaros et al.

AITD, PSO, T1D

[72]

Cataldo et al.

AITD, T1D

[73]

Neuhausen et al.

JRA, T1D

[74]

Alopecia areata

Kakourou et al.

AITD, CD, PSO, T1D, VIT

[75]


AA, alopecia areata; AdD, Addison's disease; AS, ankylosing spondylitis; AITD, autoimmune thyroid disease; CD, celiac disease; CrD, Crohn's disease; IBD, inflammatory bowel disease; IIM, idiopathic inflammatory myositis; JDM, juvenile dermatomyositis; JRA, juvenile rheumatoid arthritis; JSLE, juvenile systemic lupus erythematosus; MAS, multiple autoimmune syndrome; MG, myasthenia gravis; MS, multiple sclerosis; PA, pernicious anemia; PAN, polyarteritis nodosa; PBC, primary biliary cirrhosis; PSO, psoriasis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SS, Sjögren's syndrome; SSc, systemic sclerosis; T1D, type 1 diabetes; UC, ulcerative colitis; VIT, vitiligo; WG, Wegener's granulomatosis. Note: Although AS is considered an auto-inflammatory more than autoimmune disease [76] we show the results obtained.

Cárdenas-Roldán et al. BMC Medicine 2013 11:73   doi:10.1186/1741-7015-11-73

Open Data