Open Access Highly Accessed Research article

How do autoimmune diseases cluster in families? A systematic review and meta-analysis

Jorge Cárdenas-Roldán, Adriana Rojas-Villarraga and Juan-Manuel Anaya*

Author Affiliations

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63-C-69, Bogota, Colombia

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BMC Medicine 2013, 11:73  doi:10.1186/1741-7015-11-73

Published: 18 March 2013

Additional files

Additional file 1:

Forest plots depicting risk ratios for familial autoimmunity in first degree relatives. The figure shows two different analyses. From top to bottom: Addison's disease, autoimmune thyroid disease, ankylosing spondylitis, celiac disease, inflammatory bowel disease, discoid lupus, hemolytic anemia, inflammatory idiopathic myositis, immune thrombocytopenic purpura, localized scleroderma, pernicious anemia, myasthenia gravis, multiple sclerosis, polyarteritis nodosa, primary biliary cirrhosis, psoriasis, rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis, type 1 diabetes, vitiligo, Wegener's granulomatosis. The summary effect (random effect model) is depicted as a diamond at the bottom of each analysis. The lateral points of each diamond indicate confidence intervals for this estimate.

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Additional file 2:

Funnel plots of the three meta-analyses showing publication bias. The corresponding funnel plot shows the standard error on the Y axis and the log value for common effect size on the horizontal axis. From top to bottom: OR for Type 1 diabetes in first degree relatives, OR for multiple sclerosis in probands, RR for autoimmune thyroid disease in probands. Visual inspection of funnel plots suggested effect sizes for the mentioned analyses were scattered asymmetrically around a central effect. OR, odds ratio; RR, risk ratio.

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