Table 3

Smoking intensity (pack years) related to metabolites

Metabolites

β estimate of pack year

Δ (%)

P


(95% confidence interval)×10-3


Men

Arginine

-1.1 (-3.6, 1.4)

-0.11%

0.38

Aspartate

2.9 (-1.4, 7.1)

0.29%

0.20

Glutamate

2.9 (-1.2, 6.9)

0.29%

0.17

Ornithine

-2.4 (-5.2, 0.3)

-0.24%

0.09

Serine

1.1 (-1.3, 3.6)

0.11%

0.37

Kynurenine*

-3.3 (-6.1, -0.5)

-0.33%

0.02

PC aa C32:3

-1.4 (-4.3, 1.4)

-0.14%

0.33

PC aa C34:1

-0.9 (-3.5, 1.6)

-0.09%

0.48

PC aa C36:0

-2.3 (-4.9, 0.4)

-0.23%

0.09

PC aa C36:1

-1.4 (-4.6, 1.8)

-0.14%

0.39

PC aa C38:0

-2.1 (-4.9, 0.7)

-0.21%

0.15

PC aa C38:3

1.2 (-1.7, 4.1)

0.12%

0.43

PC aa C40:4

1.3 (-2.5, 5.1)

0.13%

0.51

PC ae C34:3*

-3.7 (-6.4, -0.9)

-0.37%

0.01

PC ae C38:0*

-3.6 (-6.6, -0.5)

-0.36%

0.02

PC ae C38:6*

-2.6 (-5.1, -0.1)

-0.26%

0.04

PC ae C40:6

-1.7 (-4.4, 1.0)

-0.17%

0.22

lysoPC a C18:2

-3.1 (-6.5, 0.3)

-0.31%

0.07


Women

Carnitine

1.1 (-4.3, 6.5)

0.11%

0.70

PC aa C32:1

0.2 (-10.5, 10.9)

0.02%

0.97

PC aa C36:1*

6.9 (0.6, 13.2)

0.69%

0.04

PC ae C34:3

-2.7 (-7.7, 2.2)

-0.27%

0.54

SM (OH) C22:2

-2.8 (-7.7, 2.2)

-0.28%

0.28

Glutamate

2.2 (-7.8, 12.2)

0.22%

0.67


Results of linear regression of smoking intensity (pack years) on metabolite concentrations in men and women, adjusted for age, body mass index and alcohol consumption. All smoking-related metabolites presented in Table 2 are listed (*P <0.05). aa: diacyl-; ae: acyl-alkyl-; CS: current smokers; FS: former smokers; lysoPC: acyl-phosphatidylcholine; NS: never smokers; PC: phosphatidylcholine; SM (OH): hydroxysphingomyeline.

Xu et al. BMC Medicine 2013 11:60   doi:10.1186/1741-7015-11-60

Open Data