Figure 6.

Protein-metabolite networks and pathways of the smoking-related metabolites and genes. (A) Network linking metabolites and proteins encoded by smoking-related genes with maximum one intermediate. Node color indicates the reversibility after smoking cessation. (B, C) Effects of smoking on arginine and glutamate as well as on lipid metabolism. Metabolites are in regular font, protein coding genes are in italic, gender-specific gene (CPS1) is in bold italic font. aa: diacyl-; ae: acyl-alkyl-; APOA5: apolipoprotein A-V; BDH: 3-hydroxybutyrate dehydrogenase, type 1; cPLA2: cytosolic phospholipase A2; CS: current smokers; FS: former smokers; GIIC sPLA2: phospholipase A2, membrane associated; LRAT: lecithin retinol acyltransferase; LYPLA1: lysophospholipase I; lysoPC: acyl-phosphatidylcholine; NOS1: nitric oxide synthase 1; NS: never smokers; PC: phosphatidylcholine; PLA2G10: group 10 secretory phospholipase A2; SCGB1A1: uteroglobin; SDH: serine dehydratase; SLC3A2: solute carrier family 3 member 2

Xu et al. BMC Medicine 2013 11:60   doi:10.1186/1741-7015-11-60
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