Table 1

Summary of Forest plots showing the associations between IL28B polymorphisms and SVR or SC.

Stratification

Subgroup

No.a

OR (95% CI)b

P value

SVR/favorable genotypec

SVR/unfavorable genotyped

Weight, %e

I2, %f

P-valueg


rs12979860


Overall

42

3.77 (3.25 to 4.37)

< 0.001

3,516/4,951

2,775/7,233

100

52.3

< 0.001


By ethnicity

A

1

3.75 (1.60 to 8.79)

0.002

18/30

28/98

1.75

NA

NA


AA

2

3.19 (0.99 to 10.29)

0.052

26/59

76/414

3.50

71.1

0.063


As

7

3.27 (2.21 to 4.84)

< 0.001

1,137/1,565

136/315

12.35

40.4

0.122


C

37

3.63 (4.01 to 4.37)

< 0.001

2,021/2,846

2,168/5,392

64.92

56.5

< 0.001


H

2

7.17 (0.56 to 92.34)

0.131

38/54

59/161

2.29

81.5

0.020


NA

1

1.67 (0.52 to 5.38)

0.393

10/16

22/44

1.14

NA

NA


Mixed

13

3.95 (2.68 to 5.83)

< 0.001

266/381

286/806

14.35

30.1

0.143


Overall

63

3.59 (3.10 to 4.15)

< 0.001

3,516/4,951

2,775/7,230

100

48.5

< 0.001


By HCV genotype

1/4

37

4.20 (3.61 to 4.90)

< 0.001

1,728/2,647

1,641/5,106

59.33

27.5

0.065


2/3

15

1.59 (1.14 to 2.21)

0.006

640/779

537/719

16.59

19.8

0.232


Mixed

11

3.97 (3.30 to 4.77)

< 0.001

1,130/1,506

577/1,386

24.07

0.0

0.581


Overall

63

3.58 (3.10 to 4.15)

< 0.001

3,498/4,932

2,755/7,211

100

48.3

< 0.001


By type of infection

HCV

57

3.55 (3.04 to 4.14)

< 0.001

3,390/4,765

2,684/6,949

92.53

51.3

< 0.001


HCV/HIV

6

4.07 (2.66 to 6.21)

< 0.001

126/186

91/284

7.47

0.0

0.436


Overall

63

3.59 (3.10 to 4.15)

< 0.001

3,516/4,951

2775/7233

100

48.4

< 0.001


rs8099917


Overall

39

3.86 (3.18 to 4.69)

< 0.001

5,222/8,106

1,298/3,733

100

71.9

< 0.001


By ethnicity

A

1

2.02 (0.88 to 4.65)

0.097

37/90

10/39

1.98

NA

NA


As

30

4.82 (3.80 to 6.11)

< 0.001

3,548/5,535

477/1740

53.23

60.3

< 0.001


C

20

2.71 (2.07 to 3.54)

< 0.001

1,314/1,982

624/1491

33.68

50.8

0.005


H

1

11.25 (3.51 to 36.00)

< 0.001

25/29

25/70

1.40

NA

NA


Mixed

5

2.27 (1.52 to 3.38)

< 0.001

298/468

162/392

9.71

34.4

0.192


Overall

57

3.63 (3.04 to 4.34)

< 0.001

5,222/8,104

1,298/3,732

100

64.0

< 0.001


By HCV genotype

1/4

37

4.55 (3.76 to 5.52)

< 0.001

3,157/5,473

815/2971

71.23

60.5

< 0.001


2/3

16

1.59 (1.22 to 2.08)

0.001

1,362/1,706

405/567

21.20

10.1

0.338


Mixed

4

3.43 (2.36 to 5.00)

< 0.001

643/850

65/162

7.57

0.0

0.733


Overall

57

3.59 (3.00 to 4.29)

< 0.001

5,162/8,029

1,285/3,700

100

64.1

< 0.001


By type of infection

HCV

50

3.78 (3.14 to 4.57)

< 0.001

4,948/7,681

1,179/3,443

90.07

65.3

< 0.001


HCV/HIV

3

3.70 (0.96 to 14.31)

0.058

56/104

11/56

3.04

58.8

0.088


Mix

4

2.07 (1.10 to 3.92)

0.025

218/321

108/234

6.89

50.3

0.110


Overall

57

3.63 (3.03 to 4.33)

< 0.001

5,222/8,106

1,298/3,733

100

64.0

< 0.001


rs12980275


Overall

6

3.95 (2.39 to 6.53)

< 0.001

1,047/1,433

575/1,353

100

77.7

< 0.001


By ethnicity

As

2

5.00 (1.65 to 15.11)

0.004

633/836

66/206

34.60

88.9

0.003


C

4

3.44 (1.38 to 8.57)

0.008

374/543

465/1,045

43.85

67.2

0.027


H

1

8.84 (2.76 to 28.34)

< 0.001

22/26

28/73

10.30

NA

NA


Mix

1

1.46 (0.50 to 4.24)

0.484

18/28

16/29

11.24

NA

NA


Overall

8

3.91 (2.31 to 6.62)

< 0.001

1,047/1,433

575/1,353

100

75.7

< 0.001


By HCV genotype

1/4

4

6.33 (2.64 to 15.16)

< 0.001

457/694

428/1,148

59.27

87.4

< 0.001


2/3

2

1.78 (0.38 to 8.25)

0.460

58/62

86/97

11.79

27.3

0.241


Mix

2

2.44 (1.38 to 4.32)

0.002

532/677

61/108

28.93

22.5

0.256


Overall

8

3.91 (2.31 to 6.62)

< 0.001

1,047/1,433

575/1,353

100

75.7

< 0.001


Subgroup

No.a

OR [95% CI]b

P value

SC/favorable genotypec

SC/unfavorable genotyped

Weight, %e

I2, %f

P-valueg


rs12979860


Overall

7

3.20 (2.03 to 5.05)

< 0.001

496/1,091

248/1230

100

81.8

< 0.001


By ethnicity

As

1

1.31 (0.79 to 2.15)

0.291

43/180

37/191

14.70

NA

NA


C

6

3.78 (2.60 to 5.50)

< 0.001

453/911

211/1,039

85.30

67.9

0.008


Overall

7

3.20 (2.03 to 5.05)

< 0.001

496/1,091

248/1,230

100

81.8

< 0.001


By HCV genotype

1

2

5.66 (3.28 to 9.77)

< 0.001

253/410

108/522

30.91

70.3

0.067


Mix

4

2.34 (1.48 to 3.69)

< 0.001

183/528

113/557

54.73

59.8

0.058


Unknown

1

2.96 (1.75 to 5.02)

< 0.001

60/153

27/151

14.37

NA

NA


Overall

7

3.20 (2.03 to 5.05)

< 0.001

496/1,091

248/1,230

100

81.8

< 0.001


rs8099917


Overall

4

3.60 (2.70 to 4.81)

< 0.001

340/1,149

72/634

100

46.6

0.132


Abbreviations: A, African; AA, African American; As, Asian; C, Caucasian; H, Hispanic; NA, North African; ND, no data; RCT, randomized controlled trial; SC, spontaneous clearance; SVR, sustained virologic response.

aNumber of studies or subgroups included for each analysis.

bPooled odds ratios were calculated by fixed or random effects models when appropriate. The significance of the pooled OR was calculated by the Z-test, and was considered significant at P < 0.05.

cNumber of patients with favorable genotype that achieved SVR or SC with respect to the total number of patients showing favorable genotype.

dSVR or SC/unfavorable genotype state for the number of patients with unfavorable genotype that achieved SVR or SC with respect to the total number of patients showing unfavorable genotype.

eRelative weight of each study's contribution to the analysis.

fRepresents the proportion of heterogeneity.

gP < 0.1 suggests presence of heterogeneity.

JimĂ©nez-Sousa et al. BMC Medicine 2013 11:6   doi:10.1186/1741-7015-11-6

Open Data