Table 1

Characteristics of placebo-controlled randomized trials giving the effects of statins on testosterone

Lead author/publicationyear/reference

Study

Participants

Authors: funding and affiliations


Setting

Duration

Statin and daily dose

Testosterone assessment method

Comments

Men

Women

Mean age, years

Health status


Statin/placebo (no. completed study)


Tobert 1982 [11]

Europe

4 weeks

Lovastatin, multiple doses

Various radio immunoassays

47/10a

0

29

Healthy volunteers

Affiliations include MSD

Dobs 2000 [16]

US

24 weeks

Simvastatin 20/40 mg/pravastatin 40 mg

Radio immunoassay

85/28

0

40

Hypercholesterolemia

Affiliations include Merck

Dobs 2000 [15]

US

12 weeks

Simvastatin 80 mg

Radio immunoassay

37/39

0

45

High LDL cholesterol

Affiliations include Merck

Hyyppä 2003 [29]

Finland

12 weeks

Simvastatin 20 mg

Direct competitive immunoassay

120/120

0

48

Hypercholesterolemia

None given

Boehm 2004 [28]

Germany

3 months

Pravastatin 40 mg

Competitive electrochemiluminescence immunoassay

6/9

4/3b

65

Hypercholesterolemia

None given

Banaszewska 2007 [26]

Poland

12 weeks

Simvastatin 20 mg

Specific chemiluminescence assay

Also using OCPs

0

45/48

24

PCOS

NIH and drug donations

Banaszewska 2009 [27]

Poland

3 months

Simvastatin 20 mg

Specific electrochemiluminescence assay

Also using metformin

0

37/36

25

PCOS

NIH and Polish State Committee for Scientific Research

Sathyapalan 2009 [30]

UK

12 weeks

Atorvastatin 20 mg

Chemiluminescent immunoassay

0

19/18

28

PCOS

Pfizer

Kazerooni 2010 [32]

Iran

12 weeks

Simvastatin 20 mg

Radio immunoassay

Also using metformin

0

42/42

25

PCOS

None

Raja-Khan 2011 [31]

US

6 weeks

Atorvastatin 40 mg

Not given

0

9/11c

33

PCOS

NIH, Penn State Univeristy, Pfizer

Rashidi 2011 [33]

Iran

8 weeks

Simvastatin 20 mg

Chemiluminescence assay

Also receiving IVF treatment

0

32/29

25

PCOS

Daru Darman Pars Co.


aSubjects with missing data excluded, but number excluded not clearly given; at least two from the statin arm were excluded.

bData not used because of an implausible value for testosterone at study end in the placebo group.

cTwo subjects with missing data excluded, but not clear from which arm(s).

IVF = in vitro fertilization; MSD = Merck, Sharp and Dohme; NIH = National Institute of Health; OCP = oral contraceptives; PCOS = polycystic ovary syndrome.

Schooling et al. BMC Medicine 2013 11:57   doi:10.1186/1741-7015-11-57

Open Data