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Open Access Highly Accessed Research article

Maternal caffeine intake during pregnancy is associated with birth weight but not with gestational length: results from a large prospective observational cohort study

Verena Sengpiel1*, Elisabeth Elind2, Jonas Bacelis1, Staffan Nilsson3, Jakob Grove4, Ronny Myhre5, Margaretha Haugen2, Helle Margrete Meltzer2, Jan Alexander6, Bo Jacobsson15 and Anne-Lise Brantsæter2

Author Affiliations

1 Department of Obstetrics and Gynaecology, Sahlgrenska Academy, Sahlgrenska University Hospital/Östra, SE-416 85 Gothenburg, Sweden

2 Norwegian Institute of Public Health, Department of Exposure and Risk Assessment, Division of Environmental Medicine, PO Box 4404 Nydalen, NO-0403 Oslo, Norway

3 Mathematical Sciences, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden

4 Department of Biomedicine, Aarhus University, Wilhelm Meyers Allé 4, DK-8000 Aarhus C, Denmark, and Bioinformatics Research Centre (BiRC), Aarhus University, CF Møllers Allé 8, DK-8000 Aarhus C, Denmark

5 Norwegian Institute of Public Health, Department of Genes and Environment, Division of Epidemiology, PO Box 4404 Nydalen, NO-0403 Oslo, Norway

6 Norwegian Institute of Public Health, Office of the Director-General, PO Box 4404 Nydalen, NO-0403 Oslo, Norway

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BMC Medicine 2013, 11:42  doi:10.1186/1741-7015-11-42

Published: 19 February 2013

Additional files

Additional file 1:

Bland-Altman plot for the difference in caffeine intake between the food frequency questionnaire (FFQ) and a four-day weighed food diary in 119 women in the validation study. Bland-Altman plot of the differences in caffeine intake between the FFQ and the food diary measurements (bias) against the mean caffeine intake by the two methods showing that the mean difference was small and not biased towards any of the methods. The median (IQR) caffeine intake in the validation study sample was 40 mg/day (18 to 88 mg/day) by the FFQ and 38 mg/day (10 to 99 mg/day) by the food diary. Spearman correlation was 0.70 (95% CI 0.59 to 0.78).

Format: PPTX Size: 67KB Download file

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