Table 2

Linear Regression Models: methylation at the IGF2 and H19 DMRs in relation to parental obesity

Linear regression models

IGF2 DMR

H19 DMR


Obesity of:

β

SE

P

β

SE

P

Model 1

Father

-3.83

1.48

0.01

+3.09

1.64

0.07

Model 2

Mother

+2.38

1.30

0.08

+2.80

1.38

0.05

Model 3

Father

Mother

-5.28

+3.08

1.62

1.48

0.003

0.05

+2.55

+1.05

1.82

1.70

0.17

0.54


Obesity was defined as BMI ≥30 kg/m2. All models were adjusted for maternal age and smoking status, as well as by the newborn's birth weight and gender. Models 1 and 2 include either maternal or paternal obesity. Model 3 includes both maternal and paternal obesity.

Soubry et al. BMC Medicine 2013 11:29   doi:10.1186/1741-7015-11-29

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