Additional file 1: Figure S1.

mRNA of growth genes in maternal blood across labor. Relative expression of mRNA coding five growth genes in paired maternal blood obtained just before labour commenced and at moment of delivery. GH: Growth Hormone; Adam12: Disintegrin and metalloproteinase domain-containing protein 12; IGFR1: Insulin Growth Factor 1 receptor; IGF: Insulin Growth Factor. Figure S2. Expression of hypoxia-induced mRNA in placentas complicated by severe preterm fetal growth restriction. Expression of five hypoxia induced mRNA in placental specimens obtained from cases of preterm controls (no fetal growth restriction, n = 8), term controls (delivered >37 weeks gestation, n = 8) and severe preterm fetal growth restriction (FGR, delivered <34 weeks gestation, n = 20). Comparisons were made between controls and the FGR cohort. Hif: hypoxia inducible factor; Adm: adrenomedullin; LdhA: lactate dehydrogenase A. *P < 0.05, **P < 0.01, ***P < 0.001. Figure S3. mRNA in maternal blood among the FGR cohort, grouped according to whether pre-eclampsia was present. Comparisons between fetal growth restriction (FGR) with no pre-eclampsia (FGR - no PET; n = 12) versus FGR with co-existent pre-eclampsia (FGR + PET; n = 8) were non-significant for all four genes (P ≥ 0.41). Remaining comparisons, as shown in the graphs, were made between both FGR groups and gestationally matched controls (controls were pregnancies that progressed to delivery of an infant of normal birthweight at term). Hif: hypoxia inducible factor; Adm: adrenomedullin; LdhA: lactate dehydrogenase A. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Table S1. Clinical characteristics for the cohort who laboured. The group was stratified according to whether the fetus was hypoxic (umbilical artery lactate concentrations >6.0 mmol/L) or not (umbilical artery lactate concentrations <6.0 mmol/L) at birth. Table S2. Expression of hypoxia-induced mRNAs in maternal blood before labor compared to moment of birth.

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Whitehead et al. BMC Medicine 2013 11:256   doi:10.1186/1741-7015-11-256