Expression of hypoxia-induced mRNA in gestational tissues obtained after labour. (A) Cluster analysis and a heatmap of 41 hypoxia induced genes in blood of fetuses from the hypoxia cohort (where umbilical artery lactate concentrations sampled from the placenta soon after birth were >6.0 mmol/L) or controls (umbilical artery lactate <6.0 mmol/L). Green indicates increased expression, red is decreased expression. Expression of hypoxia inducible factor (Hif)1α, Hif2α, adrenomedullin (Adm) and lactate dehydrogenase A ((LdhA) in (B) fetal blood and (C) placenta obtained from the hypoxia cohort (n = 4) or controls (n = 4). Mean and S.E.M. are graphed. *P <0.05.
Whitehead et al. BMC Medicine 2013 11:256 doi:10.1186/1741-7015-11-256