Open Access Research article

The contribution of major depression to the global burden of ischemic heart disease: a comparative risk assessment

Fiona J Charlson12*, Andrew E Moran3, Greg Freedman4, Rosana E Norman25, Nicolas JC Stapelberg6, Amanda J Baxter12, Theo Vos4 and Harvey A Whiteford12

Author Affiliations

1 Queensland Centre for Mental Health Research, Brisbane, Australia

2 School of Population Health, University of Queensland, Brisbane, Australia

3 Division of General Medicine, Department of Medicine, Columbia University Medical Center, New York, USA

4 Institute for Health Metrics and Evaluation, University of Washington, Seattle, USA

5 Queensland Children’s Medical Research Institute, University of Queensland, Brisbane, Australia

6 School of Psychology, Griffith University, Brisbane, Australia

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BMC Medicine 2013, 11:250  doi:10.1186/1741-7015-11-250

Published: 26 November 2013

Additional files

Additional file 1:

Description of search strategy and systematic review methodology.

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Additional file 2:

Quality scoring checklist for meta-analysis using the quality effects model.

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Additional file 3:

Search flow diagram.

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Additional file 4:

Table of studies meeting selection criteria.

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Additional file 5:

Funnel plot of included studies.

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Additional file 6:

Absolute ischemic heart disease (IHD) disability-adjusted life years (DALYs) (in 1,000 s) attributable to major depression by world region for 1990, 2005 and 2010.

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Additional file 7:

World map showing regional attributable burden as: (A) disability-adjusted life years (DALYs) per 1,000 population (95% CI) and (B)percentage of overall ischemic heart disease (IHD) DALYs, for 2010.

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