Table 6

Biomarker panels integrating maternal serum levels of the validated PE biomarkers
PE onset Early Late
Panel 0 1 0 2
sFlt-1a + - + -
PIGF + - + -
HPXa - + - +
FT - - - -
ADAM12a - - - -
HP - - - +
A2M - - - -
APO-E - - - -
APO C-IIIa - - - +
APO A-I - + - +
RBP4 - - - +
HB - - - -
FGA - - - -
pikachurin - + - +
Panel size 2 3 2 6
ROC AUC 1.00 1.00 0.86 1.00
p value 4.35E-4 1.43E-4 2.94E-4 3.65E-4

aIndicates biomarkers up-regulated in PE. Panel 0 is the benchmark panel sFlt-1/PIGF ratio; ‘+’, selected in panel; ‘-‘, unselected.

AUC: area under the curve; PE: preeclampsia; ROC: receiver operating characteristic.

Liu et al.

Liu et al. BMC Medicine 2013 11:236   doi:10.1186/1741-7015-11-236

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