Open Access Research article

Integrating multiple ‘omics’ analyses identifies serological protein biomarkers for preeclampsia

Linda Y Liu1, Ting Yang2, Jun Ji2, Qiaojun Wen2, Alexander A Morgan2, Bo Jin2, Gongxing Chen2, Deirdre J Lyell3, David K Stevenson1, Xuefeng B Ling2* and Atul J Butte1*

Author Affiliations

1 Department of Pediatrics, Stanford University, 1265 Welch Road, Room X-163 MS-5415, Stanford, CA 94305, USA

2 Department of Surgery, Stanford University, Stanford, CA 94305, USA

3 Department of Obstetrics & Gynecology, Stanford University, 269 Campus Drive, CCSR 4245A, Stanford, CA 94305, USA

For all author emails, please log on.

BMC Medicine 2013, 11:236  doi:10.1186/1741-7015-11-236

Published: 6 November 2013

Additional files

Additional file 1: Table S1:

Expression data sets used for multiplex meta analysis based PE marker discovery. Table S2. Comparison of biomarker’s abundances at early and late gestational age time points.

Format: PDF Size: 552KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2: Figure S1:

Boxplot display and scatter plot of biomarker distributions at different gestation in PE and control groups. Horizontal box boundaries and midline denote sample quartiles. Figure S2. Composite overlay of different biomarker panels’ loess fitted lines for both PE and control subjects as a function of gestation. Figure S3. The performance, gauged by ROC analyses, of PE serum protein biomarker panel 0, 1, and 2 in discriminating PE and control subjects.

Format: PDF Size: 547KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data