Table 1

Characteristics of patients (n = 86) with tuberculosis (TB) stratified by indices of disease severity and survival
Blood CD4 cell count Symptom severity C-reactive protein Hemoglobin concentration Vital status at 90 days
(cells/μL) Concentration (mg/L) (g/dL)
>200 101 to 200 0 to 100 WHO screen negative WHO screen positive + cough <2 weeks WHO screen positive + cough ≥2 weeks <20 20 to 60 61 to 200 >200 >11.0 8.0 to 11.0 <8.0 Alive at 90 days Death at 90 days
(n = 24) (n = 28) (n = 34) (n = 15) (n = 49) (n = 22) (n = 21) (n = 23) (n = 19) (n = 23) (n = 34) (n = 36) (n = 12) (n = 80) (n = 6)
Patient characteristics
Age, median (IQR) 32.9 (28.6 to 39.0) 31.1 (28.2 to 35.8) 35.5 (25.8 to 44.5) 31.5 (28.6 to 45.9) 33.7 (28.5 to 38.0) 30.5 (26.6 to 39.3) 33.7 (30.7 to 38.0) 35.5 (28.6 to 42.5) 35.2 (28.3 to 44.5) 30.6 (25.5 to 35.6) 35.3 (30.3 to 45.9) 32.9 (26.3 to 40.5) 27.6 (25.0 to 33.1) 32.5 (28.4 to 38.7) 38.6 (26.6 to 44.5)
Female (%) 14 (58.3) 19 (67.9) 22 (64.7) 10 (66.7) 32 (65.3) 13 (59.1) 13 (61.9) 16 (69.6) 13 (68.4) 13 (56.5) 14 (41.2) 29 (80.6) 9 (75.0) 51 (63.8) 4 (66.7)
BMI, median (IQR) 21.2 (20.1 to 24.0) 21.0 (19.7 to 27.4) 21.9 (18.7 to 25.9) 22.6 (19.7 to 27.6) 21.2 (19.3 to 25.0) 21.0 (18.0 to 22.3) 22.0 (20.7 to 27.1) 22.7 (20.9 to 27.6) 20.1 (17.7 to 22.1) 20.6 (18.4 to 24.3) 21.3 (20.6 to 24.5) 21.6 (18.2 to 27.1) 19.8 (17.8 to 24.0) 21.3 (19.6 to 26.0) 18.9 (17.0 to 24.0)
History of previous TB (%) 4 (16.7) 8 (28.6) 5 (14.7) 6 (40.0) 7 (14.3) 4 (18.2) 5 (23.8) 4 (17.4) 2 (10.5) 6 (26.1) 7 (20.6) 8 (22.2) 1 (8.3) 16 (20.0) 1 (16.7)
WHO stage at enrolment
1 or 2 (%) 16 (66.7) 18 (64.3) 11 (32.4) 9 (60.0) 27 (55.1) 9 (40.9) 17 (81.0) 15 (65.2) 4 (21.1) 9 (39.1) 22 (64.7) 16 (44.4) 3 (25.0) 45 (56.3) 0
3 or 4 (%) 8 (33.3) 10 (35.7) 23 (67.7) 6 (40.0) 22 (44.9) 13 (59.1) 4 (19.1) 8 (34.8) 15 (79.0) 14 (60.9) 12 (35.3) 20 (55.6) 9 (75.0) 35 (43.8) 6 (100)
Blood Tests
Hemoglobin g/dL (IQR) 11.5 (10.7 to 13.7) 10.5 (8.5 to 12.7) 9.4 (8.0 to 11.0) 11.5 (10.6 to 13.4) 10.9 (8.9 to 12.0) 8.8 (8.0 to 11.0) 11.7 (11.3 to 14.1) 11.1 (8.8 to 12.3) 10.1 (7.9 to 11.6) 9.0 (7.9 to 10.0) 12.5 (11.7 to 13.9) 9.5 (8.8 to 10.6) 7.3 (7.0 to 7.6) 10.9 (8.8 to 12.3) 9.9 (7.2 to 10.1)
Absolute neutrophil count cells/μL (IQR) 3.3 (2.5 to 4.7) 3.2 (2.4 to 4.3) 4.0 (2.5 to 6.7) 2.6 (1.9 to 3.5) 3.3 (2.4 to 5.3) 4.7 (3.0 to 7.0) 2.5 (1.9 to 3.3) 3.2 (2.5 to 5.0) 5.0 (3.4 to 6.7) 4.3 (2.6 to 9.1) 2.8 (2.0 to 3.5) 3.6 (2 .8 to 5.1) 7.2 (4.4 to 9.4) 3.3 (2.4 to 5.2) 4.9 (4.0 to 6.2)
Absolute lymphocyte count, cells/μL (IQR) 1.9 (1.6 to 2.2) 1.9 (1.4 to 2.7) 0.8 (0.6 to 1.3) 1.9 (1.3 to 2.7) 1.6 (1.1 to 2.0) 1.1 (0.7 to 1.7) 1.6 (1.4 to 2.7) 1.7 (1.0 to 2.2) 1.3 (0.6 to 1.7) 1.4 (0.7 to 2.1) 1.6 (1.3 to 2.3) 1.5 (0.9 to 2.0) 0.5 (0.4 to 1.2) 1.6 (1.1 to 2.1) 0.7 (0.6 to 0.7)
CD4 cell counts (cells/μl)
Median (IQR) 233 (211 to 275) 143 (124 to 184) 35 (21 to 68) 158 (44 to 189) 137 (68 to 213) 109 (35 to 184) 188 (138 to 235) 158 (71 to 205) 52 (21 to 205) 102 (29 to 140) 189 (114 to 235) 98 (41 to 194) 28 (16 to 107) 139 (66 to 205) 34 (29 to 62)
CD4 0 to 100 - - 34 (100) 5 (33.3) 19 (38.8) 10 (45.5) 3 (14.3) 8 (34.8) 12 (63.2) 11 (47.8) 8 (23.5) 18 (50.0) 8 (66.7) 29 (36.3) 5 (83.3)
CD4 101 to 200 - 28 (100) - 7 (46.7) 13 (26.5) 8 (36.4) 8 (38.1) 8 (34.8) 1 (5.3) 11 (47.8) 11 (32.4) 9 (25.0) 4 (33.3) 27 (33.8) 1 (16.7)
CD4 >200 24(100) - - 3 (20.0) 17 (34.7) 4 (18.2) 10 (47.6) 7 (30.4) 6 (31.6) 1 (4.4) 15 (44.1) 9 (25.0) 0 24 (30.0) 0
Log viral load (copies/ml)
Median (IQR) 4.7 (4.2 to 5.0) 4.6 (4.2 to 5.3) 5.1 (4.7 to 5.5) 4.7 (4.2 to 5.0) 4.8 (4.4 to 5.3) 4.9 (4.5 to 5.4) 4.7 (4.4 to 4.8) 4.7 (4.4 to 5.2) 4.9 (4.5 to 5.6) 5.2 (4.7 to 5.6) 4.4 (3.9 to 4.7) 5.1 (4.8 to 5.4) 5.6 (5.1 to 5.7) 4.8 (4.4 to 5.3) 5.5 (4.9 to 5.7)

Lawn et al.

Lawn et al. BMC Medicine 2013 11:231   doi:10.1186/1741-7015-11-231

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