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Which placebo to cure depression? A thought-provoking network meta-analysis

Florian Naudet123*, Bruno Millet23, Philippe Charlier45, Jean Michel Reymann67, Anne Solène Maria18 and Bruno Falissard189

Author Affiliations

1 INSERM U669, Maison de Solenn, 97 Boulevard de Port Royal, 75679 Paris Cedex 14, France

2 Université de Rennes 1, EA-4712 Behavior and Basal Ganglia Unit, Rennes, France

3 Centre Hospitalier Guillaume Régnier, Service Hospitalo-Universitaire de Psychiatrie, Rennes, France

4 Department of Forensic Medicine and Pathology, University Hospital R. Poincaré (AP-HP, UVSQ), Garches, France

5 Laboratory of Medical Ethics, University of Paris 5, 45 St Pères Street, 75006 Paris, France

6 Centre d’Investigation Clinique CIC-P INSERM 0203, Hôpital de Pontchaillou, Centre Hospitalier Universitaire de Rennes et Université de Rennes 1, Rennes, France

7 Laboratoire de Pharmacologie Expérimentale et Clinique, Faculté de Médecine, CS34317, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France

8 Université Paris-Sud and Université Paris Descartes, UMR-S0669, Paris, France

9 AP-HP, Hôpital Paul Brousse, Département de santé publique, Villejuif, France

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BMC Medicine 2013, 11:230  doi:10.1186/1741-7015-11-230

Published: 25 October 2013

Additional files

Additional file 1: Table S1:

Studies included and their quality assessment according to the standardized critical appraisal instrument from the Joanna Briggs Institute. Table S2. Head to head meta-analyses (using fixed-effects model (Mantel-Haenszel = MH) and random-effects (DerSimonian and Laird = DSL)) of response and remission between 1) placebo vs fluoxetine, 2) placebo vs venlafaxine and 3) fluoxetine vs venlafaxine. Table S3. Akaïke’s Information Criterion (AIC) for fixed effect and random effects meta-analyses of response and remission. Table S4. Odds ratio (OR) of response and remission between fluoxetine placebo, venlafaxine placebo, fluoxetine/venlafaxine placebo, fluoxetine and venlafaxine. Figure S1. Forest plot presenting head-to-head meta-analyses using random-effects model for response and remission comparing 1) placebo vs fluoxetine, 2) placebo vs venlafaxine and 3) fluoxetine vs venlafaxine.

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