Table 3

Risk of total acute myocardial infarction by dietary n-3 LCPUFA (as a percentage of total energy intake) and fish (grams) tertiles
Non-diabetes (HbA1c <5.7%, n = 1,012) Pre-diabetes (HbA1c ≥5.7%, n = 1,049) Diabetes (n = 317)a
Age/sex adjusted Multivariateb Age/sex adjusted Multivariateb Age/sex adjusted Multivariateb
Number of events 77 88 43
n-3 LCPUFA
Tertile 1c 1.00 1.00 1.00 1.00 1.00 1.00
Tertile 2d 1.12 (0.63, 2.02) 0.93 (0.49, 1.77) 1.16 (0.69 to 1.95) 1.20 (0.70, 2.06) 0.43 (0.21, 0.88) 0.48 (0.22, 1.06)
Tertile 3e 1.45 (0.84, 2.53) 1.55 (0.87, 2.76) 1.16 (0.69, 1.95) 1.33 (0.77, 2.28) 0.38 (0.18, 0.80) 0.38 (0.17, 0.83)
P for trend 0.17 0.11 0.59 0.30 0.007 0.01
Total fish
Tertile 1f 1.00 1.00 1.00 1.00 1.00 1.00
Tertile 2g 1.68 (0.97, 2.89) 1.51 (0.84, 2.72) 0.85 (0.50, 1.44) 0.88 (0.51, 1.52) 0.87 (0.44, 1.71) 0.94 (0.45, 1.98)
Tertile 3h 1.02 (0.55, 1.88) 1.19 (0.63, 2.27) 1.05 (0.63, 1.74) 1.10 (0.65, 1.85) 0.56 (0.26, 1.24) 0.66 (0.29, 1.53)
P for trend 0.96 0.60 0.84 0.70 0.16 0.34

Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards. aDiabetes was defined as clinically diagnosed, or as having a fasting glucose ≥7.0 or a non-fasting glucose ≥11.1 mmol/L. bMultivariate model adjusted for age (continuous), sex, fasting (yes or no), current smoker (yes or no), extent of coronary artery disease (non-significant; single, double, or triple vessel), left ventricular ejection fraction (continuous), serum triglycerides (continuous), baseline acute coronary syndrome (yes or no), baseline percutaneous coronary intervention (yes or no), baseline coronary artery bypass graft surgery (yes or no), and treatment with folic acid or vitamin B6 supplements (yes or no). cn = 337 in non-diabetic, n = 349 in pre-diabetic, and n = 105 in diabetic patients. dn = 338 in non-diabetic, n = 350 in pre-diabetic, and n = 106 in diabetic patients. en = 337 in non-diabetic, n = 350 in pre-diabetic, and n = 106 in diabetic patients. fn = 339 in non-diabetic, n = 354 in pre-diabetic, and n = 105 in diabetic patients. gn = 335 in non-diabetic, n = 342 in pre-diabetic, and n = 108 in diabetic patients. hn = 338 in non-diabetic, n = 353 in pre-diabetic, and n = 104 in diabetic patients. HbA1c, glycosylated hemoglobin; n-3 LCPUFA, n-3 long-chain polyunsaturated fatty acids (eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid).

Strand et al.

Strand et al. BMC Medicine 2013 11:216   doi:10.1186/1741-7015-11-216

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