Table 5 |
||
| Similarities in mitochondral and brain dysfunctions between encephalomyelitis disseminata/multiple sclerosis (ED/MS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) | ||
| Mitochondrial dysfunctions | ED/MS | ME/CFS |
| Depleted ATP production (muscle and brain) | ✓ | ✓ |
| Decreased phosphocreatine resynthesis following exercise | ✓ | ✓ |
| Impaired oxidative phosphorylation | ✓ | ✓ |
| Acceleration of glycolysis | ? | ✓ |
| Damage to mitochondrial respiratory chain in neurons | ✓ | ? |
| Oxidative mitochondrial damage | ✓ | ✓ |
| Mitochondrial energy failure | ✓ | ✓ |
| Brain dysfunctions: | ||
| Cerebral hypoperfusion | ✓ | ✓ |
| Reduced cerebral glucose metabolism | ✓ | ✓ |
| Gray matter atrophy | ✓ | ✓ |
| Increased cerebral lactate | ✓ | ✓ |
| Increased cerebral choline | ✓ | ✓ |
| Reduced levels of N-acetyl aspartate | ✓ | ✓ |
Morris and Maes
Morris and Maes BMC Medicine 2013 11:205 doi:10.1186/1741-7015-11-205
