Figure 2.

The significant neuroimmune overlaps in multiple sclerosis (MS) and myalgic encephalomyelitis/chronic fatigue syndrome (MS/CFS) may be based on shared immunoinflammatory, oxidative and nitrosative stress (O+NS), autoimmune and mitochondrial pathways, and brain dysfunctions. CMI = cell-mediated immunity; NKCA: natural killer cell activity; PICs = proinflammatory cytokines; Th = T helper; Treg = T regulatory.