Table 1

Summary of laboratory parameters
PBO + MET (n = 137) DAPA 2.5 mg + MET (n = 137) DAPA 5 mg + MET (n = 137) DAPA 10 mg + MET (n = 135)
Sodium (mmol/L)
n 72 77 87 93
Baseline 138.9 (2.3) 138.5 (2.9) 138.6 (2.3) 139.1 (2.2)
Change at week 102 -0.04 (2.7) 0.2 (2.8) 0.1 (2.6) 0.1 (2.6)
P vs PBO + MET 0.1434 0.1905 0.3978
Potassium (mmol/L)
n 72 77 87 93
Baseline 4.35 (0.47) 4.34 (0.46) 4.37 (0.39) 4.37 (0.43)
Change at week 102 -0.08 (0.55) -0.01 (0.45) -0.05 (0.35) -0.07 (0.47)
P vs PBO + MET 0.3366 0.4563 0.9918
Serum creatinine (μmol/L)
n 72 77 88 93
Baseline 76.9 (17.9) 78.7 (18.1) 79.6 (19.3) 77.8 (17.8)
Change at week 102 -0.9 (10.3) -1.8 (9.7) -3.5 (12.7) -2.7 (10.6)
P vs PBO + MET 0.9954 0.4720 0.9032
Serum uric acid (μmol/L)a
n 28 35 47 57
Baseline 314 (79) 322 (80) 323 (88) 323 (80)
Change at week 102 -1.78 (54.13) -55.9 (50.32) -46.4 (64.36) -52.9 (64.36)
P vs PBO + MET 0.0054 0.0013 0.0002
Blood urea nitrogen (mmol/L)
n 72 77 88 93
Baseline 5.33 (1.55) 5.51 (1.41) 5.65 (1.81) 5.34 (1.41)
Change at week 102 0.56 (1.24) 0.70 (1.54) 0.42 (1.87) 0.73 (1.44)
P vs PBO + MET 0.2299 0.4169 0.0845
Haematocrit (%)
n 71 78 87 93
Baseline 42.61 (3.90) 42.38 (3.99) 42.15 (3.59) 42.88 (3.95)
Change at week 102 -1.43 (3.29) 0.84 (2.53) 1.35 (2.48) 1.54 (2.78)
P vs PBO + MET <0.0001 <0.0001 <0.0001
Haemoglobin (g/L)
n 71 78 87 94
Baseline 142.8 (13.45) 142.5 (14.25) 141.6 (12.19) 143.6 (13.10)
Change at week 102 -4.9 (10.14) 1.5 (7.73) 3.1 (8.40) 4.1 (8.84)
P vs PBO + MET <0.0001 <0.0001 <0.0001
Systolic blood pressure (mm Hg)
n 72 78 88 94
Baseline 128 (15) 127 (14) 127 (14) 126 (16)
Change at week 102 1.5 (13.7) 0.7 (16.1) -1.1 (13.2) -0.3 (15.0)
P vs PBO + MET 0.1111 0.0136 0.0067
Diastolic blood pressure (mm Hg)
n 72 78 88 94
Baseline 81 (9) 80 (9) 81 (9) 79 (10)
Change at Week 102 -1.0 (7.9) -0.1 (8.1) -1.5 (8.1) -1.2 (10.1)
P vs PBO + MET 0.6605 0.2140 0.1075

Data are means (SD) at baseline or mean changes (SD) from baseline at week 102 including data after rescue unless noted. n is the number of treated patients with non-missing baseline and Week 102 values for the specific test. aExcluding data after rescue. Abbreviations: SD standard deviation, SE standard error, PBO placebo, MET metformin, DAPA dapagliflozin.

Bailey et al.

Bailey et al. BMC Medicine 2013 11:193   doi:10.1186/1741-7015-11-193

Open Data