Table 1

Examples of pharmacogenomics tests regarding responses or toxicities to drug treatments
Disease area Host genotype Treatment References
Optimizing drug efficacy
Chronic hepatitis C IL28B Pegylated interferon alpha, Ribavirin [127-129]
Breast cancer, other tumors Anthracyclines, poly(adenosine diphosphate-ribose) polymerase inhibition [117,130-132]
Preventing drug toxicities
HIV type 1 (HLA)-B*5701 Abacavir [1,4,35,106,133]
Rheumatic and inflammatory bowel disorders Thiopurine methyl transferase genotypes Azathioprine [19-21,58,59,133-135]
HLA-B*58:01 Allopurinol
Gastrointestinal cancers Dehydropyrimidine dehydrogenase deficiency 5-fluorouracil [136]
UGT1A1 polymorphism Irinotecan [137]

Godman et al.

Godman et al. BMC Medicine 2013 11:179   doi:10.1186/1741-7015-11-179

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