Table 2

PTH, immunoglobulins and complement C4 and C3 levels compared among four concentration ranges of 25(OH)D in 1,291 healthy older subjects
Analyte 25(OH)D
<10 10 to 20 21 to 29 ≥30 P-value
N = 103 N = 403 N = 404 N = 381
Trend Sd/Nor+
PTH 7.87 ± 0.51* 4.78 ± 0.13 4.25 ± 0.10 3.73 ± 0.10 <0.01 <0.01
pg/ml
IgA 2.32 ± 0.10 2.12 ± 0.05 2.22 ± 0.05 2.12 ± 0.05 0.12 0.036
mg/ml
IgE 145.38 ± 50.1 75.45 ± 10.08 85.01 ± 13.17 70.37 ± 7.89 0.28 >0.05
kU/l
IgM 0.88 ± 0.05 0.94 ± 0.04 0.96 ± 0.03 0.98 ± 0.03 0.09 >0.05
mg/ml
IgG 10.63 ± 0.25 10.05 ± 0.11 10.28 ± 0.10 10.28 ± 0.12 0.24 >0.05
mg/ml
IgG1 6.74 ± 0.21 6.16 ± 0.08 6.17 ± 0.07 6.41 ± 0.11 0.14 0.033
mg/ml
IgG2 3.13 ± 0.15 3.23 ± 0.07 3.45 ± 0.07 3.24 ± 0.06 0.01 >0.05
mg/ml
IgG3 0.38 ± 0.02 0.37 ± 0.01 0.38 ± 0.01 0.41 ± 0.03 0.37 >0.05
mg/ml
IgG4 0.66 ± 0.06 0.60 ± 0.03 0.66 ± 0.03 0.59 ± 0.02 0.12 >0.05
mg/ml
C4 0.22 ± 0.01 0.23 ± 0.00 0.23 ± 0.00 0.23 ± 0.00 0.02 0.01
mg/ml
C3 1.11 ± 0.02 1.09 ± 0.01 1.7 ± 0.007 1.07 ± 0.01 0.03 0.01
mg/ml

* Mean ± 1 SD.

+Sd/Nor: between the groups of Severely deficient and Normal serum concentrations of 25(OH)D.

Differences between groups were assessed by Kruskal-Wallis test.

Sakem et al.

Sakem et al. BMC Medicine 2013 11:176   doi:10.1186/1741-7015-11-176

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