Table 5

Rate ratios for immune-mediated diseases following admission for vitamin D deficiency (coded as such)
Autoimmune condition O E RR (95% CI) P-value
Addison’s disease 12 1.7 7.0 (3.6 to 12.3) <0.001
Ankylosing spondylitis 10 5.3 1.9 (0.9 to 3.5) 0.06
Asthma (aged 5 to 54) 83 278.9 0.3 (0.2 to 0.4) <0.001
Celiac disease 38 8.6 4.4 (3.1 to 6.1) <0.001
Crohn’s disease 33 10 3.3 (2.3 to 4.6) <0.001
Diabetes mellitus (aged 0 to 29) 20 6.2 3.2 (2.0 to 5.0) <0.001
Idiopathic thrombocyt. purpura 5 5 1.0 (0.3 to 2.3) 0.83
Multiple sclerosis 12 8.2 1.5 (0.8 to 2.6) 0.25
Myxoedema 177 328.2 0.5 (0.5 to 0.6) <0.001
Pemphigoid 10 2.7 3.7 (1.8 to 6.8) <0.001
Pernicious anemia 34 19.6 1.7 (1.2 to 2.4) 0.002
Primary biliary cirrhosis 7 2.4 2.9 (1.2 to 6.0) 0.008
Psoriasis 18 28.9 0.6 (0.4 to 1.0) 0.05
Rheumatoid arthritis 101 74.5 1.4 (1.1 to 1.7) 0.003
Sjogren’s syndrome 12 5.7 2.1 (1.1 to 3.7) 0.01
Systemic lupus erythematosus 28 5.3 5.3 (3.5 to 7.7) <0.001
Thyrotoxicosis 67 35.9 1.9 (1.5 to 2.4) <0.001
Ulcerative colitis 21 13.6 1.5 (0.9 to 2.3) 0.06

O Observed number of cases, E Expected number, RR Rate ratio, 95% CI 95% confidence interval.

Ramagopalan et al.

Ramagopalan et al. BMC Medicine 2013 11:171   doi:10.1186/1741-7015-11-171

Open Data