Table 1

Age-distribution of people in exposure cohorts, percentage who were female, and numbers in reference cohort1
Exposure condition Age at admission N in the exposure cohort (% of total) % female Number in the reference cohort2
Rickets, osteomalacia, or vitamin D deficiency, all combined: <15 745 (7.5) 53.0 889,364
15 to 44 532 (24) 72.4 2,906,048
45 to 64 1,191 (26.7) 70.4 2,206,093
65 to 74 1,356 (15.1) 68.9 1,198,951
75+ 1,697 (26.7) 73.1 1,403,767
All ages 19,338 (100) 70.1 8,604,223
Rickets: <15 494 (54.8) 48.9 889,495
15 to 44 73 (16.8) 70.4 2,907,044
45 to 64 32 (8.7) 71.0 2,207,541
65 to 74 29 (7) 68.6 1,200,051
75+ 42 (12.7) 78.2 1,405,341
All ages 1,228 (100) 59.5 8,609,472
Osteomalacia: <15 1 (0.1) 0.0 889,562
15 to 44 39 (16.9) 68.8 2,906,823
45 to 64 275 (30.3) 62.7 2,207,108
65 to 74 503 (20.5) 68.3 1,199,703
75+ 585 (32.2) 76.7 1,404,882
All ages 5,191 (100) 69.4 8,608,078
Vitamin D deficiency: <15 263 (6) 56.8 889,428
15 to 44 436 (27.5) 73.5 2,906,311
45 to 64 911 (26.9) 74.0 2,206,566
65 to 74 847 (13.8) 69.5 1,199,332
75+ 1,107 (25.8) 71.5 1,404,315
All ages 13,260 (100) 71.5 8,605,952

1 The reference cohort consisted of people admitted with the following conditions coded under the Office of Population, Censuses and Surveys (OPCS) code edition 4 for operations and ICD10 code for diagnosis (with equivalent codes used for other coding editions): appendectomy (OPCS4 H01 to H03), adenoidectomy (E20), tonsillectomy (F34 + F36), dilation and curettage (Q10.3 + Q11.4), total hip replacement (W37 to W39), total knee replacement (W40 to W42), squint (ICD10 H49 to H51), cataract (H25), otitis externa/media (H60 to H67), varicose veins (I83), hemorrhoids (I84), deflected septum, nasal polyp (J33 + J34.2), impacted tooth and other disorders of teeth (K00 to K03), inguinal hernia (K40), in-growing nail, toenail and other diseases of the nails (L60), sebaceous cyst (L72.1), bunion (M20.1), internal derangement of the knee (M23), dislocations, sprains and strains (S03, S13, S23, S33, S43, S53, S63, S73, S83, S93), selected limb fractures (S42, S52, S62, S82, S92), superficial injury and contusion (S00, S10, S20, S30, S40, S50, S60, S70, S80, S90), contraceptive management (Z30).

2 The numbers in the reference cohort vary slightly depending on what the exposure condition is. This is because individuals, who otherwise fulfilled the criteria for inclusion in the reference cohort, were removed from the reference cohort if they fulfilled the criteria for inclusion in the exposure cohort (see Methods).

Ramagopalan et al.

Ramagopalan et al. BMC Medicine 2013 11:171   doi:10.1186/1741-7015-11-171

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