Table 1

Study populations, inputs, and outcomes used to construct each of the risk scores used in this study
Score Populationa Inputs Outcome
Non-laboratory-based (Gaziano et al., 2008) [8] NHANES I (US, 1971 to 1975) Age, sex, smoking, diabetes, systolic blood pressure, treatment for hypertension, BMI CVD death, MI, stroke, CHF, coronary bypass, PTCA
Framingham CVD 2008 (D’Agostino et al., 2008) [11] Framingham, MA, US (1968 to 1987) Age, sex, smoking, diabetes, systolic blood pressure, treatment for hypertension, total cholesterol, HDL cholesterol MI, angina, coronary insufficiency, CHD death, stroke, TIA, CHF, PVD, CVD death
Framingham CVD (Anderson et al., 1991) [10] Framingham, MA, (US., 1968 to 1975) Age, sex, smoking, diabetes, systolic blood pressure, total cholesterol, HDL cholesterol Same as above
Framingham CHD (Anderson et al., 1991) [10] Same as above Same as above MI, CHD death, angina, coronary insufficiency
SCORE, high risk (Conroy et al., 2003) [4] High risk European countriesb Age, sex, smoking, systolic blood pressure, total cholesterol Death from: hypertensive disease, IHD, cerebrovascular disease
SCORE, low risk (Conroy et al., 2003) [4] Low risk European countriesc Same as above Same as above
CUORE (Giampaoli et al., 2007) [12] Italy (1983 to 1997) Age, sex, smoking, diabetes, systolic blood pressure, treatment for hypertension, total cholesterol, HDL cholesterol Fatal and non-fatal MI or stroke

aYears indicate when baseline values were collected; bapplicable for all non-low risk European countries; capplicable for Belgium, France, Greece, Italy, Luxembourg, Portugal, Spain, and Switzerland. BMI, body-mass index; CHD coronary heart disease, CHF congestive heart failure, CVD cardiovascular disease, HDL high-density lipoprotein, IHD ischemic heart disease, MI myocardial infarction, NHANES National Health and Nutrition Examination Survey, PTCA percutaneous transluminal coronary angioplasty, PVD peripheral vascular disease, TIA transient ischemic attack.

Gaziano et al.

Gaziano et al. BMC Medicine 2013 11:170   doi:10.1186/1741-7015-11-170

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