Additional file 8: Table S3.
Enrichment of autoimmune disease susceptibility regions within VDR binding sites. Autoimmune susceptibility regions were defined as those within 100kb of SNPs associated with autoimmune disease . 25(OH)D≥75 = subjects with vitamin D levels ≥75 nM, 25(OH)D<75 = subjects with vitamin D levels <75 nM, O/E = observed/expected overlap of genomic intervals, p = p-value calculated from 10,000 Monte-Carlo randomisations, p(genes) = p-value controlling for position of genes calculated from 1,000 Monte-Carlo randomisations, p(immune genes) = p-value controlling for position of immune-related genes calculated from 1,000 Monte-Carlo randomisations. P(genes) and p(immune genes) are calculated only for enrichment with uncontrolled p<0.05.
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Handel et al. BMC Medicine 2013 11:163 doi:10.1186/1741-7015-11-163