Is network meta-analysis as valid as standard pairwise meta-analysis? It all depends on the distribution of effect modifiers
1 Mapi, 180 Canal Street, Suite 503, Boston, MA 02114, USA
2 Tufts University School of Medicine, 145 Harrison Avenue, Boston, MA 02111, USA
3 LSE Health & Social Care, London School of Economics & Political Science, Cowdray House, 20 Houghton Street, London WC2A 2AE, UK
BMC Medicine 2013, 11:159 doi:10.1186/1741-7015-11-159Published: 4 July 2013
Additional file 1:
Equations to illustrate that the imbalance in the distribution of effect modifiers across different types of direct comparisons violates the consistency assumption of network meta-analysis and result in biased indirect estimates.
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