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Is network meta-analysis as valid as standard pairwise meta-analysis? It all depends on the distribution of effect modifiers

Jeroen P Jansen12* and Huseyin Naci3

Author Affiliations

1 Mapi, 180 Canal Street, Suite 503, Boston, MA 02114, USA

2 Tufts University School of Medicine, 145 Harrison Avenue, Boston, MA 02111, USA

3 LSE Health & Social Care, London School of Economics & Political Science, Cowdray House, 20 Houghton Street, London WC2A 2AE, UK

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BMC Medicine 2013, 11:159  doi:10.1186/1741-7015-11-159

Published: 4 July 2013

Additional files

Additional file 1:

Equations to illustrate that the imbalance in the distribution of effect modifiers across different types of direct comparisons violates the consistency assumption of network meta-analysis and result in biased indirect estimates.

Format: DOCX Size: 50KB Download file

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