Table 2

Factors that may affect the differential drug response of patients of African ancestry
Category Factors
Environmental Diet (sodium) [2]
Bioavailability Absorption, First pass metabolism (intestinal and phase 1 drug metabolism, polymorphisms cytochrome P450 enzymes, phase 2 drug metabolism) [6,9]
Distribution Protein binding, distribution volume
Receptor Receptor sensitivity and genetic variation [6,9]
Hemodynamics Low renin, sodium-volume dependent hypertension [2]
Intracellular effects Nitric oxide, cGMP, cAMP, calcium fluxes, ion transport, rho kinase, creatine kinase, myosin light chain kinase, myosin ATPase [10-12]
Elimination Kidney, liver or other route

Brewster and Seedat

Brewster and Seedat BMC Medicine 2013 11:141   doi:10.1186/1741-7015-11-141

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