Figure 3.

Pharmacodynamics of thiazide diuretics. This is a schematic reproduction of the kidney distal convoluted tubule. Sodium retention is driven by basolateral Na+K+ ATPase throughout the kidney [86]. Creatine kinase (CK), reported to be high in persons of African ancestry [11,12,72,73], is tightly bound near basolateral Na+K+ ATPase, where it rapidly regenerates ATP to facilitate sodium retention [87]. Enhanced sodium retention occurs more frequently in persons of African ancestry [96]. Thiazide diuretics counteract this effect, albeit indirectly and partly, through inhibition of luminal Na+Cl -cotransport.

Brewster and Seedat BMC Medicine 2013 11:141   doi:10.1186/1741-7015-11-141
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