Table 2

Research domain criteria, October 2012 (constructs are listed within each domain)
Negative valence domain Positive valence systems Cognitive systems Systems for social processes Arousal/modulatory systems
Acute threat (‘fear’) Approach motivation Attention Affiliation and attachment Arousal
Potential threat (‘anxiety’) Initial responsiveness to reward Perception Social communication Biological rhythms
Sustained threat Sustained responsiveness to reward Working memory Perception and understanding of self Sleep-wake
Loss Reward learning Declarative memory Perception and understanding of others
Frustrative nonreward Habit Language behavior
Cognitive (effortful) control

Cuthbert and Insel

Cuthbert and Insel BMC Medicine 2013 11:126   doi:10.1186/1741-7015-11-126

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