Open Access Research article

How well do clinical prediction rules perform in identifying serious infections in acutely ill children across an international network of ambulatory care datasets?

Jan Y Verbakel1*, Ann Van den Bruel2, Matthew Thompson2, Richard Stevens2, Bert Aertgeerts1, Rianne Oostenbrink3, Henriette A Moll3, Marjolein Y Berger4, Monica Lakhanpaul5, David Mant2, Frank Buntinx16 and the European Research Network on Recognising Serious Infection (ERNIE)

Author Affiliations

1 Department of General Practice, KU Leuven, Kapucijnenvoer 33 blok J, 3000 Leuven, Belgium

2 Department of Primary Care Health Sciences, University of Oxford, New Radcliffe House, Woodstock Road, Oxford, OX2 6GG, UK

3 Erasmus MC - Sophia's Children Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands

4 Department of General Practice, University Medical Center Groningen, Hanze plein 1 Box 30001 9700RB Groningen, The Netherlands

5 Department of General and Adolescent Paediatrics, University College London, Institute of Child Health, London, UK

6 Research Institute Caphri, Maastricht University, PB 313, Nl 6200 MD, Maastricht, The Netherlands

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BMC Medicine 2013, 11:10  doi:10.1186/1741-7015-11-10

Published: 15 January 2013

Additional files

Additional file 1:

Details of the clinical prediction rules identified in the systematic review. CRT, capillary refill time; RR, respiratory rate; Temp, temperature.

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Additional file 2:

variables and proxies used for validation of clinical prediction rules. N = Number of children in dataset; % n/N = Percentage of cases (n) out of all children (N) used for the external validation analysis; green font indicate original variable, red font,variable not recorded, blue font, proxy variable. aDerivation study (italic). b'Clinical sick impression' used as proxy for 'physician's gut feeling that something is wrong', c'Respiratory distress' used as proxy for 'dyspnoea'. d'Chest flaring' used as proxy for 'dyspnoea'. e'Meningeal irritation' used as proxy for 'nuchal rigidity'. f'Unconsciousness' used as proxy for 'coma'.

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Additional file 3:

Variables and proxies used for fever guidelines validation. N. number of children in dataset; % n/N. percentage of cases (n) out of all children (N) used for the external validation analysis; green font. original variable

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Additional file 4:

Sensitivity analyses. CI, confidence interval;

    underlined
, 95% CIs not comparable.

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