Open Access Research article

Maintenance N-acetyl cysteine treatment for bipolar disorder: A double-blind randomized placebo controlled trial

Michael Berk12345*, Olivia M Dean145, Sue M Cotton23, Clarissa S Gama6, Flavio Kapczinski6, Brisa Fernandes78, Kristy Kohlmann4, Susan Jeavons4, Karen Hewitt4, Kirsteen Moss109, Christine Allwang10119, Ian Schapkaitz4, Heidi Cobb9, Ashley I Bush4, Seetal Dodd15 and Gin S Malhi89

Author Affiliations

1 Deakin University, School of Medicine, Barwon Health, P.O. Box 291, Geelong, 3220, Australia

2 Orygen Youth Health Research Centre, 35 Poplar Rd, Parkville, 3052, Australia

3 Centre of Youth Mental Health, University of Melbourne, 35 Poplar Rd, Parkville, 3052, Australia

4 Mental Health Research Institute, University of Melbourne, Kenneth Myer Building, 30 Royal Parade, 3052, Parkville, Australia

5 University of Melbourne, Department of Psychiatry, Level 1 North, Main Block, Royal Melbourne Hospital, Parkville, 3052, Australia

6 Laboratory of Molecular Psychiatry, INCT for Translational Medicine, CNPq. Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90010-000, Brazil

7 Post-graduate Program in Biological Sciences: Biochemistry, Federal University of Rio Grande do Sul - UFRGS -, Porto Alegre, 90035-000, Brazil

8 Laboratory of Calcium Binding Proteins in the Central Nervous System, Department of Biochemistry, Federal University of Rio Grande do Sul - UFRGS -, Porto Alegre, 90035-000, Brazil

9 Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, 2006, Australia

10 CADE Clinic, Department of Psychiatry, Level 5 Building 36 Royal North Shore Hospital, St. Leonards, 2065, Australia

11 Department of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar der TU, München, Ismaninger Str. 22, 81675, Münich, Germany

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BMC Medicine 2012, 10:91  doi:10.1186/1741-7015-10-91

Published: 14 August 2012

Additional files

Additional file 1:

Timetable for assessments during the open label and maintenance phases of the trial. This table provides an outline of the trial schedule and timing of rating scale and associated trial interview delivery.

Format: DOCX Size: 19KB Download file

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