Resolution:
## Figure 1.
Illustration of antibiotic resistance dynamics in a hospital setting. The solid lines represent infection, recovery and patient turnover. Dashed lines
represent the effects of HGT and mutation. Stress-induced genetic variation would
result in an increased weight of the dashed lines under antibiotic stress. X, S, R_{1}, R_{2 }are the frequencies of uninfected patients, patients infected with susceptible bacteria,
and patients with bacteria resistant to antibiotics 1 and 2, respectively. They enter
the hospital with rates , and leave with a rate proportional to their frequency, where the patient turnover
rate, m , is the proportion constant. Infected patients turn uninfected either through spontaneous
recovery due to the immune system (at rate γ), or due to antibiotic treatment (at rate τ). χ_{1 }and χ_{2 }determine which amount of antibiotics 1 and 2 are used, respectively. Uninfected patients
become infected at rate β multiplied by the frequencies of cleared and infected patients. R_{1,2 }denotes the fraction of patients infected with double resistant bacteria, assumed
to be zero at the beginning. HGT, horizontal gene transfer.
Obolski and Hadany |