Open Access Research article

Development and description of measurement properties of an instrument to assess treatment burden among patients with multiple chronic conditions

Viet-Thi Tran12, Victor M Montori3, David T Eton3, Dan Baruch4, Bruno Falissard56 and Philippe Ravaud127*

Author Affiliations

1 Université Paris Descartes, Faculté de Médecine, Paris, France

2 INSERM U738, Paris, France

3 Division of Health Care and Policy Research, Department of Health Sciences Research and Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, USA

4 Université Paris Denis-Diderot, Faculté de Médecine, Paris, France

5 INSERM U669, Paris, France

6 Université Paris Sud, Paris, France

7 Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA

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BMC Medicine 2012, 10:68  doi:10.1186/1741-7015-10-68

Published: 4 July 2012

Additional files

Additional file 1:

Appendix 1. Demographic and clinical characteristics of patients included in the semistructured interview pretest (n = 22).

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Additional file 2:

Appendix 2. Characteristics of the items presented to patients (n = 502 patients).

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Additional file 3:

Appendix 3. Eigenvalues for the correlation matrix.

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Additional file 4:

Appendix 4. Association of items of the Treatment Burden Questionnaire and global score (n = 502 patients).

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Additional file 5:

Appendix 5. Dendogram of the hierarchical ascendant classification of patients by their answers to the Treatment Burden Questionnaire (n = 502 patients).

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Additional file 6:

Appendix 6. (a). Linear regression analysis of relation between global score for Treatment Burden Questionnaire as assessed by patients with variables associated with treatment workload. (b) Linear regression analysis of relation between global score for Treatment Burden Questionnaire as assessed by physicians with variables associated with treatment workload.

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Additional file 7:

Appendix 7. (a) Agreement between patients and informal caregiver evaluations of the treatment burden (n = 39). (b) Bland and Altman plot representing agreement between Treatment Burden Questionnaire global scores for patients and informal caregivers (n = 39).

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Additional file 8:

Appendix 8. Agreement between patients and physician evaluations of the treatment burden (n = 396).

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Additional file 9:

Appendix 9. Validation of the instrument in different subgroups.

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Additional file 10:

Appendix 10. (a) Reliability using test-retest (n = 211). (b) Bland and Altman plot representing the test-retest reliability of the Treatment Burden Questionnaire global score (n = 211).

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