Table 1

The main neglected tropical diseases for which there are single dose treatments available for disease control.

Group

Generic name or disease

Species

Geographical

distribution

Vector or intermediate host

Main drugs available to treat infections

Control measures


Nematode

Large roundworm

Ascaris lumbricoides

Worldwide

None, as

all species are directly

soil-transmitted

Albendazole

Mebendazole

Oxantel/pyrantel

Sanitation,

personal hygiene

Whipworm

Trichuris trichiura

Hookworm

Ancylostoma duodenale

Worldwide

Sanitation,

wearing shoes

Hookworm

Necator americanus


Nematode

Lymphatic filariasis

Wuchereria bancrofti

Worldwide

Mosquitoes

DEC or Ivermectin +

Albendazole

Mosquito

control

Lymphatic filariasis

Brugia malayi

South Asia


Nematode

River blindness

Onchocerca volvulus

Africa, South America

Black flies

Ivermectin

Black fly control


Trematode

Urinary schistosomiasis

Schistosoma haematobium

Africa

Fresh-water snails

Praziquantel

Snail control, sanitation and behavior change

Intestinal

schistosomiasis

Schistosoma mansoni

Africa, South America

Intestinal

schistosomiasis

Schistosoma japonicum

Asia


Bacterium

Trachoma

Chlamydia trachomatis

Worldwide

Fliesa

Azithromycin or Tetracycline

Fly control,

personal hygiene


aNo developmental stage, transmission is passive.

Hall et al. BMC Medicine 2012 10:41   doi:10.1186/1741-7015-10-41

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