Table 3

List of colon tissue-specific proteins which have not been previously studied as serum cancer or benign disease biomarkers

Gene

Protein name

Proteome identified in:

CM proteome from colon cancer cell lines

Non-colon proteome


CEACAM7

Carcinoembryonic antigen-related cell adhesion molecule 7

√ CM proteome from Hep 3B [52]; pancreatic juice proteome [33]

CLCA1

Chloride channel accessory 1

√ Normal, Down Syndrome amniotic fluid [22,23]

GPA33

Glycoprotein A33

√ LS174Ta, LS180a, Colo205 [52]

LEFTY1

Left-right determination factor 1

ZG16

Zymogen granule protein 16 homolog (rat)

√ CM proteome from Hep 3B [52]


aCM proteome of colon cancer cell lines (GS Karagiannis et al., unpublished work). CM: conditioned media.

Prassas et al. BMC Medicine 2012 10:39   doi:10.1186/1741-7015-10-39

Open Data