Microglial numbers per neuron in epilepsy relative to APOE genotype IL-1α-immunoreactive microglia (green) clustered around individual ApoE-immunoreactive neuron soma (red) in a 21-year-old APOE ε3,3 (A) and a 34-year-old APOE ε4,4 (B) patient. A maximum of 8 microglia per neuron were present in APOE ε3,3 patients compared to four or fewer in APOE ε4,4 patients (C). Overall, APOE ε3,3 patients had twice as many microglia per neuron as did APOE ε4,4 patients. Nuclei were stained with DAPI (blue). White arrows denote neurons with microglia.
Aboud et al. BMC Medicine 2012 10:35 doi:10.1186/1741-7015-10-35