Open Access Highly Accessed Research article

Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells

Yong Zhao1*, Zhaoshun Jiang2, Tingbao Zhao3, Mingliang Ye4, Chengjin Hu5, Zhaohui Yin2, Heng Li6, Ye Zhang7, Yalin Diao4, Yunxiang Li4, Yingjian Chen5, Xiaoming Sun5, Mary Beth Fisk8, Randal Skidgel9, Mark Holterman10, Bellur Prabhakar11 and Theodore Mazzone1

Author Affiliations

1 Section of Endocrinology, Diabetes & Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 West Polk Street, Chicago, IL 60612 USA

2 Section of Endocrinology, General Hospital of Jinan Military Command, 25 Shifan Road, Jinan, Shandong 250031, P.R. China

3 Stem Cell Treatment Center, General Hospital of Jinan Military Command, 25 Shifan Road, Jinan, Shandong 250031, P.R. China

4 Section of Blood Transfusion, General Hospital of Jinan Military Command, 25 Shifan Road, Jinan, Shandong 250031, P.R. China

5 Section of Molecular Diagnostics, General Hospital of Jinan Military Command, 25 Shifan Road, Jinan, Shandong 250031, P.R. China

6 Section of Neuronology, Jinan Central Hospital, 105 Jiefang Road, Jinan, Shandong 250020, P.R. China

7 Jinan Tianhe Stem Cell Biotechology Co. Ltd., 750 Shunhua Road, Jinan, Shandong 250055, P.R. China

8 Texas Cord Blood Bank, 6211 IH-10 West, San Antonio, TX 78201 USA

9 Department of Pharmacology, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, IL 60612 USA

10 Department of Surgery, University of Illinois at Chicago, 420 NE GLen Oak, Suite 201, Peoria, IL 61603 USA

11 Department of Immunology and Microbiology, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, IL 60612 USA

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BMC Medicine 2012, 10:3  doi:10.1186/1741-7015-10-3

Published: 10 January 2012

Additional files

Additional file 1:

Additional file 1 on materials and methods. 1. Supplemental methods. 2. Supplemental Figure S1. 3. Supplemental Figure S2.

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