Table 1

Studies evaluating the diagnostic value of soluble urokinase-type plasminogen activator receptor (suPAR) levels

First author, publication date [ref]

Type

Pathology

Patients

Period

Main results

Comments


Kofoed, 2007 [23]

Prospective

Suspected sepsis

156 adult, samples taken at ED admission

12 months

AUC bacterial sepsis:

suPAR 0.5, PCT 0.72

CRP 0.81

Yilmaz, 2010 [22]

Retrospective

CCHF

100 infected adult pts vs volunteers.

Samples taken at hospital admission

2006-2009

38 months

Patients (6.2 ± 4.2 ng/ml) versus controls (2.3 ± 0.6 ng/ml), P < 0.0001. Cut-off 3.06 ng/ml

AUC 0.94 (PPV 95%, specificity 92%)

No other infections studied

Østergaard, 2004 [24]

Prospective

CNS infection

183 adults, samples taken at admission

1988 to 2002

Higher CSF levels in infected patients and in patients with purulent meningitis versus those with lymphocytic meningitis (P < 0.001)

Low sensitivity and specificity (69% and 71%) with cut-off value of 1.50 mcg/l

Koch, 2011 [26]

Prospective

Critical illness medical ICU

273 adults, 197 septic patients, samples taken at ICU admission

Undefined

AUC sepsis suPAR 0.615 PCT 0.857 CRP 0.780

Correlation with renal and hepatic function

Donadello, 2011 [27]

Prospective

Critical illness medico-surgical ICU

152 adults, 55 septic patients.

Samples taken at ICU admission

December 2010 to March 2011

AUC sepsis 0.75 (95% CI 0.66 to 0.83); correlation with CRP in global population (r = 0.48), not in septic patients (r = 0.18)

Preliminary data


AUC, area under the curve; CCHF. Crimean Congo Hemorrhagic Fever; CNS,central nervous system; CRP, C- reactive protein; CSF, cerebrospinal fluid; ED, emergency department; PCT; procalcitonin; PPV, positive predictive value.

Donadello et al. BMC Medicine 2012 10:2   doi:10.1186/1741-7015-10-2

Open Data