Location(s) of BRMS1 and corresponding activities. BRMS1 is a transcription co-repressor and can shuttle between nucleus and cytoplasm. BRMS1 levels are governed by ubiquitin-mediated degradation. In the nucleus, it shows inhibition of some transcripts and up-regulation others. However, some of these regulations may be due to its cytoplasmic activities (such as deacetylation of NFκB members). The ultimate impact of BRMS1 on a specific tumor cell appears to be tumor type and context-dependent. Abbreviations: BRMS1, breast cancer metastasis suppressor-1; FABP7, fatty acid binding protein-7; ING-4, inhibitor of growth family, member-4; Cul3, Cullin-3; SPOP, speckle-type POZ domain protein; mSin3, mammalian Sin3; HDAC, histone deacetylase; Cx32, 43, connexin-32, -43; uPA, urokinase-type plasminogen activator; OPN, osteopontin; miR, micro ribonucleic acid; Nexin6, sorting nexin-6.
Riker and Samant BMC Medicine 2012 10:19 doi:10.1186/1741-7015-10-19