Table 3 

Lesion statistics from serial fluidattenuated inversion recovery (FLAIR) imaging 

Comparisons 
No. of new lesions 
No. of subjects 
t Test 
P value 


t1 to t2 
0.08 (0.82) 
12 
0.35 
0.732 
t2 to t3 
0.36 (0.64) 
11 
1.90 
0.087 
t3 to t4 
0.17 (0.52) 
6 
0.79 
0.465 
Volume change of lesions 

t1 to t2 
54.9 (247.4) 
12 
0.77 
0.458 
t2 to t3 
38.3 (116.9) 
11 
1.09 
0.302 
t3 to t4 
100.42 (237.7) 
6 
1.03 
0.348 


t1 = timepoint 1, start of the race; t2 = timepoint 2, after an average distance of 2,326 km; t3 = timepoint 3, after an average distance of 4,005 km from t1; t4 = timepoint 4, followup measurements around 8 months after finishing the race. No. of new lesions = across participants averaged number of new lesions (SD) observed between two consecutive timepoints. No. of subjects = number of subjects with two consecutive FLAIR measurements to enter a paired t test. Volume change of lesions = for calculation of lesion volumes see Methods section, shown is the difference between averaged sums of lesion volumes obtained at two consecutive timepoints, units are mm^{3}. 

Freund et al. BMC Medicine 2012 10:170 doi:10.1186/1741701510170 