Table 2

Comparison of the results of the random-effects meta-analysis (relative proportion of patients with resolved metabolic syndrome (MetS) and difference in mean)

Total (95% CI)

Model

Point Estimate d

95% CI (lower to upper)


The ratio of proportions patients with resolved MetS (7 interventions)a

Random

2.0

1.5 to 2.7

Bayesian

2.4

1.5 to 5.5

Fixed

1.9

1.7 to 2.2


Mean difference (7 interventions) b

Fasting blood glucose, mg/dl

Random c

-11.5

-22.4 to -0.6

(5 interventions)

Bayesian

-5.1

-8.6 to -0.9

Fixed

-18.7

-20.4 to -17.0

Waist circumference, cm

(6 interventions)

Random c

-2.7

-4.6 to -0.9

Bayesian

-2.6

-4.6 to -0.6

Fixed

-2.0

-2.1 to -1.9

SBP, mmHg

Random c

-6.4

-9.7 to -3.2

Bayesian

-7.9

-12.3 to -3.9

Fixed

-3.1

-3.6 to -2.7

DBP, mmHg

Random c

-3.3

-5.2 to -1.4

Bayesian

-3.5

-6.2 to -0.97

Fixed

-2.0

-2.3 to -1.8

Triglyceride, mg/dl

Random c

-12.0

-22.2 to -1.7

Bayesian

-4.8

-28.1 to 18.8

Fixed

-18.7

-20.4 to -17.0

HDL, mg/dl

Random c

1.3

-0.6 to 3.1

Bayesian

0.7

-2.4 to 3.8

Fixed

2.9

2.5 to 3.3


a8 interventions including estimated data denote 2.0 (1.5 to 2.5) for the random-effects, 2.7 (1.6 to 5.8) for the Bayesian, and 1.9 (1.7 to 2.2) for the fixed model, respectively. Number of subjects that could have resolved MetS = 1400 (intervention) and 1439 (control), 2839 in total. Proportions of resolved patients = 35.0% (intervention) and 17.6% (control). bNumber of subjects for mean difference = 379 (intervention) and 369 (control), 748 in total. c Random = DerSimonian-Laird method, 95% CI = 95% confidence interval.

d The estimates by the sensitivity analyses using r = 0.3 and r = 0.7 were the same with r = 0.5 for fasting blood glucose and waist circumference, and it varied for SBP (-7.1, -6.4), DBP (-3.6, -2.9), triglycerides (-12.7, -11.5), and HDL (0.9, 1.6). The estimates by the subgroup analyses using 4 interventions [18,20,21] (random-effects model) denote -3.1 (-5.3 to -0.9) for fasting blood glucose, -3.1 (-5.2 to -1.0) for waist circumference, -5.1 (-8.8 to -1.9) for SBP, -2.3 (-3.3, -1.3) for DBP, -11.5 (-22.4 to -0.6) for triglyceride, and 1.5 (-0.6 to 3.47) for HDL.

Yamaoka and Tango BMC Medicine 2012 10:138   doi:10.1186/1741-7015-10-138

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