Perinatal nicotine exposure induces asthma in second generation offspring
1 Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center at David Geffen School of Medicine, 1124 West Carson Street, Torrance, 90502, USA
2 Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 1975 Zonal Avenue, Los Angeles, 90033, USA
BMC Medicine 2012, 10:129 doi:10.1186/1741-7015-10-129Published: 30 October 2012
Additional File 1:
Rat Model of Multigenerational Nicotine-induced Asthma. Rats were exposed to nicotine in utero (F0) to mimic maternal cigarette smoking. F0 offspring were then mated to generate F1 offspring, which in turn were mated to generate F2 offspring. Lungs, ovaries and testes are shown in black or white to symbolize direct or multigenerational nicotine exposure effects, respectively.
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