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Perinatal nicotine exposure induces asthma in second generation offspring

Virender K Rehan1*, Jie Liu1, Erum Naeem1, Jia Tian1, Reiko Sakurai1, Kenny Kwong1, Omid Akbari2 and John S Torday1

Author Affiliations

1 Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center at David Geffen School of Medicine, 1124 West Carson Street, Torrance, 90502, USA

2 Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 1975 Zonal Avenue, Los Angeles, 90033, USA

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BMC Medicine 2012, 10:129  doi:10.1186/1741-7015-10-129

Published: 30 October 2012

Additional files

Additional File 1:

Rat Model of Multigenerational Nicotine-induced Asthma. Rats were exposed to nicotine in utero (F0) to mimic maternal cigarette smoking. F0 offspring were then mated to generate F1 offspring, which in turn were mated to generate F2 offspring. Lungs, ovaries and testes are shown in black or white to symbolize direct or multigenerational nicotine exposure effects, respectively.

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