Table 4

Altered genes in microarray according to prostatic disease status (overall, OB/OW or lean group)

Probe set

Gene Name

Gene Description

Fold Change

P


Extra Prostatic Cancer versus Benign Prostatic Hyperplasia

All subjects

7952313

MIRLET7A2

microRNA let-7a-2

2.00

4.26E-06

7957540

MRPL42

mitochondrial ribosomal protein L42

1.63

5.49E-06

7980891

TC2N

tandem C2 domains; nuclear

2.25

8.26E-06

7915468

CCDC23

coiled-coil domain containing 23

1.70

1.93E-05

8002020

TPPP3

tubulin polymerization-promoting protein family member 3

1.66

8.62E-05

7980861

CATSPERB

cation channel; sperm-associated; beta

1.84

1.48E-04

7964927

TSPAN8

tetraspanin 8

1.91

2.31E-04

8168463

FGF16

fibroblast growth factor 16

1.67

2.93E-04


Lean subjects

7952313

MIRLET7A2

microRNA let-7a-2

2.12

9.04E-05

8024485

GADD45B

growth arrest and DNA-damage-inducible; beta

-1.56

9.47E-04

7957540

MRPL42

mitochondrial ribosomal protein L42

1.60

9.86E-04


OB/OW subjects

7980861

CATSPERB

cation channel; sperm-associated; beta

2.50

1.91E-06

7980891

TC2N

tandem C2 domains; nuclear

2.98

4.31E-06

7908488

CFHR1

complement factor H-related 1

1.88

3.16E-05

8078529

STAC

SH3 and cysteine rich domain

1.50

5.79E-05

7902400

SNORD45B

small nucleolar RNA; C/D box 45B

-5.18

1.9E-04

7908459

CFH

complement factor H

1.70

3.0E-04

7952313

MIRLET7A2

microRNA let-7a-2

1.88

4.0E-04

7957540

MRPL42

mitochondrial ribosomal protein L42

1.65

4.0E-04

7958019

DRAM1

DNA-damage regulated autophagy modulator 1

1.55

5.3E-04

7969640

CLDN10

claudin 10

1.59

6.3E-04

8076586

SCUBE1

signal peptide; CUB domain; EGF-like 1

-1.73

7.2E-04

8027862

FFAR2

free fatty acid receptor 2

-1.58

9.2E-04


Organ Confined Prostate Cancer versus Benign Prostatic Hyperplasia

All subjects

7919349

RNU1-1

RNA; U1 small nuclear 1

-2.18

1.50E-07

7919576

RNU1-1

RNA; U1 small nuclear 1

-1.96

2.47E-07

7952313

MIRLET7A2

microRNA let-7a-2

1.79

6.21E-05

7980891

TC2N

tandem C2 domains; nuclear

1.98

6.26E-05

7978568

RNU1-1

RNA; U1 small nuclear 1

-1.65

9.43E-05

7981964

SNORD116-8

small nucleolar RNA; C/D box 116-8

-1.91

1.07E-04

8004184

XAF1

XIAP associated factor 1

-1.64

8.67E-04


Lean subjects

8001067

HERC2P4

hect domain and RLD 2 pseudogene 4

-1.77

1.22E-06

7997239

PDXDC2

pyridoxal-dependent decarboxylase domain containing 2

-2.12

2.69E-06

8000692

BOLA2

bolA homolog 2 (E, coli)

-1.52

3.41E-06

8000651

SMG1

SMG1 homolog; phosphatidylinositol 3-kinase-related kinase (C. elegans)

-1.61

3.76E-06

8019655

TBC1D3B

TBC1 domain family; member 3B

-1.56

1.26E-05

7919349

RNU1-1

RNA; U1 small nuclear 1

-2.30

2.27E-05

7927513

FAM21C

family with sequence similarity 21; member C

-1.66

2.31E-05

7993359

NPIP

nuclear pore complex interacting protein

-1.53

4.30E-05

8014633

TBC1D3

TBC1 domain family; member 3

-1.55

5.53E-05

8014437

TBC1D3G

TBC1 domain family; member 3G

-1.51

6.27E-05

7994026

NPIPL3

nuclear pore complex interacting protein-like 3

-1.69

9.02E-05


OB/OW subjects

7969640

CLDN10

claudin 10

2.01

7.04E-06

7980891

TC2N

tandem C2 domains; nuclear

2.31

1.10E-04

7952313

MIRLET7A2

microRNA let-7a-2

2.06

1.74E-04

8021101

HAUS1

HAUS augmin-like complex; subunit 1

1.61

3.10E-04

8165698

MIR1977

microRNA 1977

-3.03

3.46E-04

8060854

PLCB1

phospholipase C; beta 1 (phosphoinositide-specific)

1.53

5.95E-04


Extra Prostatic Cancer versus Organ Confined Prostate Cancer

All subjects

7919349

RNU1-1

RNA; U1 small nuclear 1

1.71

1.86E-05

7981964

SNORD116-8

small nucleolar RNA; C/D box 116-8

1.88

1.85E-04

7940287

MS4A1

membrane-spanning 4-domains; subfamily A; member 1

-2.15

2.74E-04


Lean subjects

8001067

HERC2P4

hect domain and RLD 2 pseudogene 4

2.06

5.14E-08

8000692

BOLA2

bolA homolog 2 (E, coli)

1.52

3.37E-06

7997239

PDXDC2

pyridoxal-dependent decarboxylase domain containing 2

2.00

6.36E-06

8000651

SMG1

SMG1 homolog; phosphatidylinositol 3-kinase-related kinase (C. elegans)

1.57

6.75E-06

7927513

FAM21C

family with sequence similarity 21; member C

1.74

8.44E-06

7993359

NPIP

nuclear pore complex interacting protein

1.51

5.38E-05

7994026

NPIPL3

nuclear pore complex interacting protein-like 3

1.73

5.61E-05

8119595

RPL7L1

ribosomal protein L7-like 1

1.63

5.71E-05

7990943

GOLGA6L10

golgin A6 family-like 10

1.55

6.08E-05

7919349

RNU1-1

RNA; U1 small nuclear 1

1.93

2.25E-04


OB/OW subjects

7980861

CATSPERB

cation channel; sperm-associated; beta

1.78

2.92E-04

7982006

SNORD116-29

small nucleolar RNA; C/D box 116-29

1.77

5.84E-04


The bold ones with adjusted P <0.2

Ribeiro et al. BMC Medicine 2012 10:108   doi:10.1186/1741-7015-10-108

Open Data