Table 3 |
||||||
|
Randomized trials of preoperative RT compared to alternative treatments in rectal cancer. |
||||||
|
Trial (Reference) |
Treatment |
No. Patients |
Local Failure (%) |
Survival Rate at 5 years (%) |
||
|
|
||||||
|
Preoperative RT |
Surgery Delay |
Postoperative RT (Delay) |
||||
|
|
||||||
|
Pahlman & Glimelius [30] |
5.1 Gy × 5 - |
1 week - |
- 60 Gy in 54* (4–6 weeks) |
236 235 |
22% 33% p = 0.012 |
43% 37% p = 0.43 |
|
RTOG [31] |
0.5 Gy × 1 - |
1 day - |
45–51 Gy* (2–6 weeks) |
175 178 |
32% 32% p = NS |
43% 32% p = NS |
|
Herrmann et al. [32] |
3.3 Gy × 5 - |
1–2 days - |
41.5 Gy in 48* 59.8 Gy in 56* (6–14 weeks) |
48 46 |
25% 39% p = 0.142 |
49% 37% p = NS |
|
EORTC [33] |
2.3 × 15 2.3 × 15 + 5-FU |
2 weeks 2 weeks |
- - |
121 126 |
15% 15% p = NS |
59% 46% p = 0.06 |
|
Francois et al. [34] |
3.0 Gy × 13 3.0 Gy × 13 |
2 weeks 6–8 weeks |
- - |
99 102 |
9% 9% p = NS |
78%† 73%† p = NS |
|
|
||||||
|
Note: NS indicates not statistically significant; RTOG, Radiation Therapy Oncology Group. * Radiation given only to high-risk cases (stages B2 and C). † 3-year survival rate. |
||||||
|
Figueredo et al. BMC Medicine 2003 1:1 doi:10.1186/1741-7015-1-1 |
||||||
