Endothelio-hematopoietic relationship: getting closer to the beginnings
Institute for Stem Cell Research, MRC Centre for Regenerative Medicine, 5 Little France Drive, Edinburgh EH16 4UU, Scotland, UK
BMC Biology 2011, 9:88 doi:10.1186/1741-7007-9-88Published: 28 December 2011
The close association between hematopoietic and endothelial cells during embryonic development led to the proposal that they may originate from a common ancestor - the hemangioblast. Due to a lack of unique specific markers for in vivo cell fate tracking studies, evidence supporting this theory derives mainly from in vitro differentiation studies. Teixeira and colleagues describe a novel enhancer that drives specific eGFP expression in blood islands of the electroporated chick embryo, thereby presenting a tool potentially suitable for analysis of hemangioblast differentiation and development of blood islands.