Table 1

The main replicated risk variants identified for schizophrenia with their locations and effect sizes

Confirmed common risk variants for schizophrenia

Chomosome

Variant

P-value

Odds Ratio

95% CI

Gene

Reference


1p21.3

rs1625579

1.5 × 10-11

1.12

1.09-1.16

MIR 137

[8]

2p15.1

rs2312147

1.9 × 10-9

1.09

VRK2

[13]

2q32.1

rs1344706

2.5 × 10-11

1.1

1.07-1.14

ZNF804A

[9]

2q32.3

rs17662626

4.65 × 10-8

1.2

1.13-1.26

[8]

6p21.3-p22.1*

rs2021722

2.18 × 10-12

1.15

1.11-1.19

HLA region

[8,10-12]

8p23.2

rs10503253

1.45 × 10-8

1.16

1.11-1.21

CSMD1

[8]

8q21.3

rs7004633

2.75 × 10-8

1.1

1.07-1.14

[8]

10q24.32*

rs7914558

2.23 × 10-8

1.22

1.15-1.29

CNNM2

[8]

11q24.2

rs12807809

2.8 × 10-9

1.16

1.09-1.24

NRGN

[8,11]

18q21.2*

rs12966547

2.35 × 10-8

1.4

1.28-1.52

TCF4

[8,10-12]

Confirmed rare variant risks for schizophrenia

Chomosome CNV type

Position (Mb)

P-value

Odds Ratio

95% CI

Gene

Reference

1q21.1 del

143.8-146.6

2.2 × 10-8

8.3

3.7-19.9

[21-23]

1q21.1 dup

143.8-146.6

2 × 10-3

3.7

1.5-8.7

[23]

2p16.3 del

50.7-51.3

5.5 × 10-9

8.2

3.8-19.4

NRXN1

[23,25]

3q29 del

197.2-198.83

4 × 10-4

2.9

[23,24]

7q36.3 dup

158.7-158.81

8.3 × 10-5

16.4

3.11, infinity

VIPR2

[23,24]

15q11.2 del

20.3-20.8

6 × 10-4

2.73

1.5-4.89

[22]

15q13.3 del

28.2-30.6

2 × 10-9

9.9

4.3-24.4

[21-23]

16 dup

9.09-9.12

1 × 10-4

12.9

2.8-121.4

C16orf72

[23]

16p11.2 dup

15.0-18.0

1.5 × 10-12

11.6

5.6-29.3

[23]

16p13.1 dup

29.5-30.2

7 × 10-3

3.27

1.29-7.94

[26]

17p12 del

14.0-15.4

5 × 10-5

10

not presented

[27]

22q11 del

17.1-19.9

< 1.0 × 10-16

44

35.9-infinity

[23]


The Odds Ratio (OR) is a measure of effect size. It is the ratio of the odds of the variant occuring in the group of people with disease versus the ratio in the control group.

The 95% confidence interval (CI) gives the range within which the true OR lies with a 95% probability.

CNV denotes a copy number variant, which may either be a deletion (del) or duplication (dup).

An asterisk indicates that more than one variant has been implicated at this locus. Details for rare variants are provided where only one gene is implicated; typically, the other CNVs implicate 10 to 20 or more genes.

Corvin BMC Biology 2011 9:77   doi:10.1186/1741-7007-9-77

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