Additional file 4.

Figure S3. Potential outcomes of double-strand break repair during break-induced replication. With the occurrence of a double-strand break (DSB) during replication, 5' to 3' strand recession occurs, followed by strand invasion to a homologous duplex for reestablishment of the replication fork. (1) Occurrences of the DSBs at a unique region. (2) When the DSB occurs at a repeated region, two outcomes are possible: (a) strand invasion at homologous repeats or (b) strand invasion across different copies of the repeat to produce a new genomic environment as the recombinant MSH1 prevents DNA exchange beyond the region of sequence homology within the repeated sequence.

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Davila et al. BMC Biology 2011 9:64   doi:10.1186/1741-7007-9-64